High-Throughput Bioscience Center

Overview of Services

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The High-Throughput Bioscinece Center's mission is to provide researchers at Stanford with the ability to run high-throughput chemical, siRNA, cDNA, and high-content screens for the purpose of drug and/or target discovery. The HTBC is a Stanford University School of Medicine core facility and was created in 2003 by the Department of Chemical and Systems Biology (formerly Molecular Pharmacology). The HTBC is a shared resource (Bioscience Screening Facility) for the Stanford Cancer Institute, and the NIH Clinical and Translational Science Award (Spectrum).

This high-throughput screening (HTS) laboratory allows Stanford researchers and others to discover novel modulators of targets that otherwise would not be practical in industry. The center incorporates instrumentation (purchased with NCRR NIH Instrumentation grant numbers S10RR019513 and S10RR026338), databases, compound libraries, and personnel whose previous sole domains were in industry. Among our instrumentation are a Molecular Devices ImageXpress Micro High-Content fluorescence microplate imager, with live cell and phase contrast/brightfield options, a Caliper Life Sciences SciClone ALH3000 and an Agilent Bravo microplate liquid handler, and the Molecular Devices Analyst GT and FlexStation II 384 and Tecan Infinite M1000 fluorescence, luminescence and absorbance multimode microplate readers. We have over 130,000 small molecules for compound screens, 15,000 cDNAs for genomic screens, and whole genome siRNA libraries targeting the human genome (the siARRAY whole human genome siRNA library from ThermoFisher Scientific, formerly Dharmacon, targeting 21,000 human genes) and the mouse genome (Qiagen mouse whole genome siRNA set V1 against ~17,000 genes).

Getting Started

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Non-Stanford Users: Click to LOGIN with approved iLab credentials. Or, click to SIGN UP for an iLab account.

Visit the Customer Help Manual for further guidance using iLab's Core Facility Services.

Leadership

David E. Solow-Cordero, Ph.D. | HTBC Director

Phone: (650) 725-6002

Fax: (650) 725-6003

Email: desolow at stanford.edu

Location and Hours of Operation

Location

Hours

High-Throughput Bioscience Center

Stanford University Medical Center

CCSR Room 0133 - North Wing

269 Campus Dr.

Stanford, CA 94305-5174

9 a.m. - 5 p.m., Monday to Friday

24/7 access for trained users

Directions:

The HTBC is located in Room 0133 of the CCSR building (basement of the North Wing). Dave's office, CCSR 0133A, is located inside the lab. For directions click here and for a campus map click here.

Links and Resources

Visit our core website for more information: http://htbc.stanford.edu/

Publication Acknowledgement

As with all Stanford Service Centers, credit must be given to High-Throughput Bioscience Center for data that results in a publication. If the work done at High-Throughput Bioscience Center produces data resulting in a figure in a publication, you are required to acknowledge High-Throughput Bioscience Center in the publication. Further, if High-Throughput Bioscience Center staff members provided significant experimental design, data interpretation, or other intellectual contribution (as evaluated by the PI), then it is expected that these individuals will be coauthors on the publication.

Contacts

Name	Role	Phone	Email	Location
David Solow-Cordero, Ph.D.	Director	650.725.6002	desolow@stanford.edu	CCSR 0133A
James K. Chen, Ph.D.	Executive Director, HTBC	(650) 725-3582	jameschen@stanford.edu	CCSR 3155C
Jason Wu	HTBC Research Assistant	(650) 725-6004; Lab: (650) 736-7638; HT Imaging Rm: (650) 736-0084	jjwu@stanford.edu	CCSR 0133

Fixed Cost Services

Name	Description	Price
Assay Development (per HTS)	(view additional details)	External Non-Profit (with PTA) $1,000.00 each
Compound Libraries Fee (per HTS)	(view additional details)	External For Profit (with PTA) $5,000.00 each External Non-Profit (with PTA) $3,500.00 each
Consulting - Assay Development (per hour)	(view additional details) 1 hour minimum charge	External Non-Profit (with PTA) $65.00 each External For Profit (with PTA) $85.00 each
Consulting - Database (per hour)	(view additional details) 1 hour minimum charge	External Non-Profit (with PTA) $95.00 each External For Profit (with PTA) $135.00 each
HTS Database (per HTS)	(view additional details)	External Non-Profit (with PTA) $3,500.00 each External For Profit (with PTA) $5,000.00 each

Search available services: View: by category alphabetically

Name	Description	Price
▼ ► Consulting Services (2)
Consulting - Assay Development (per hour)	(view additional details) 1 hour minimum charge	External Non-Profit (with PTA) $65.00 each External For Profit (with PTA) $85.00 each
Consulting - Database (per hour)	(view additional details) 1 hour minimum charge	External Non-Profit (with PTA) $95.00 each External For Profit (with PTA) $135.00 each
▼ ► High-Throughput Screening Services (3)
Name	Description	Price
Assay Development (per HTS)	(view additional details)	External Non-Profit (with PTA) $1,000.00 each
Compound Libraries Fee (per HTS)	(view additional details)	External For Profit (with PTA) $5,000.00 each External Non-Profit (with PTA) $3,500.00 each
HTS Database (per HTS)	(view additional details)	External Non-Profit (with PTA) $3,500.00 each External For Profit (with PTA) $5,000.00 each

Available Equipment and Resources

▼ ► Detection Systems (3)

▼ ► Imaging Systems (1)

▼ ► Liquid Handling Systems (6)

Map

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